Dale S. Gregerson, PhD

Professor, Department of Ophthalmology and Visual Neurosciences

Dale S. Gregerson

Contact Info

Office Phone 612-626-0772

Fax 612-626-0781

Office Address:
Department of Ophthalmology & Visual Neurosciences
314 Lions Research Building
2001 6th Street SE
Minneapolis, MN 55455

Graduate School, University of British Columbia

Summary

Awards & Recognition

  • ARVO Silver Fellow, 2008
  • 'Senior Scientific Investigator Award', Research to Prevent Blindness, 1989
  • 'James S. Adams Research Scholar Award', Research to Prevent Blindness, 1983
  • NIH Post-Doctoral Traineeship, 1976-1978
  • Medical Research Council of Canada Predoctoral Traineeship, 1972-76

Research

Research Summary/Interests

  • Immunology and the eye
  • Retinal antigens
  • Immunity in neurodegeneration/neuroprotection

Publications

Publications

Peer-Reviewed Publications

  • McPherson SW, Heuss ND, Pierson MJ, Gregerson DS. Retinal antigen-specific regulatory T cells protect against spontaneous and induced autoimmunity and require local dendritic cells. J Neuroinflam. 2014;11(1): 205. PMID: 25498509; doi:10.1186/s12974-014-0205-4
  • Heuss ND, Pierson MJ, Montaniel KRC, McPherson SW, Lehmann U, Hussong SA, Ferrington DA, Low WC, Gregerson DS. Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice. J Neuroinflam. 2014;11(1):143. [Epub ahead of print] PMID: 25116321. doi:10.1186/s12974-014-0143-1
  • McPherson SW, Heuss ND, Gregerson DS. Local “On-Demandgeneration and function of antigen specific FoxP3+ regulatory T cells in retina. J Immunol. 2013;190:4971-4981. PMCID: PMC3646944
  • Maldonado M, Kapphahn RJ, Terluk MR, Heuss ND, Yuan C, Gregerson DS, Ferrington DA. Immunoproteasome deficiency modifies the alternative pathway of NFkB signaling. PLoS One PONE-D-12-31871R1, 2013. PMCID: PMC3572990
  • Ferrington DA, Roehrich H, Chang AA, Huang CW, Maldonado M, Bratten W, Rageh AA, Heuss ND, Gregerson DS, Nelson EF, Yuan, C. Corneal wound healing is compromised by immunoproteasome deficiency. PLoS One: PONE-D-12-21067R1, 2013. PMCID: PMC3554767
  • McPherson SW, Heuss ND, Gregerson DS. Regulation of CD8+ T cell responses to retinal antigen by local FoxP3+ regulatory T cells. Front Immunol. 2012; 3:166. PMCID: PMC3380377
  • Ferrington DA, Gregerson DS. Immunoproteasome: Structure, function and antigen presentation. Prog Mol Biol Transl Sci. 2012;109:75-112. PMID: 22727420
  • Heuss, ND, Lehmann U, Norbury CC, McPherson SW, Gregerson DS. Local activation of dendritic cells alters the pathogenesis of autoimmune disease in the retina. J Immunol. 2012;188:1191-1200. PMCID: PMC3266064
  • McPherson SW, Heuss ND, Lehmann U, Gregerson DS. Generation of regulatory T cells to antigen expressed in the retina. Curr Immunol Rev. 2011;7:344-349.
  • Lehmann U, Heuss ND, McPherson SW, Roehrich H, Gregerson DS. Dendritic cells are early responders to retinal injury. Neurobiol Dis., 40:177-184, 2010. PMCID: PMC2926161 

Books

Book Chapters

  • Gregerson, D.S., Use of a ß-galactosidase reporter coupled to cell-specific promoters to examine differentiation of neural progenitor cells in vivo and in vitro. In: Stem Cells and Regenerative Medicine. Editors; Low, W.C, and Verfaillie, C.M. World Scientific, Hackensack, N.J.: 2008.

Presentations

Invited Oral Presentations at International Professional Meetings, Conferences

  • "Local generation of Tregs in the retina, and its dependence on retinal DC,” Association for Research in Vision and Ophthalmology, Ocular Immunity, Autoimmunity and Inflammation, October 7-10, 2014, Fort Lauderdale, FL
  • "Analysis of retinal antigen-specific Tregs and dendritic cells in T cell responses and EAU" International Society for Eye Research (ISER), July, 2014, San Francisco, CA
  • "Peripheral generation of regulatory CD4 T cells to antigen of retinal origin", International Symposium on Autoimmunity, June, 2010, Munich
  • Killing neurons - or Not: Immunomodulation on Demand, 2008 ARVO Summer Eye Research Conf, Monterey CA
  • "Evidence for extra-thymic, retinal generation of regulatory T cells", Workshop on Animal Models in Ocular Inflammation, 9th IOIS Symposium, Sept, 2007, Paris, France
  • "Antigen presentation in uveitis", 26th Cambridge Ophthalmological Symposium, September 11-13, 1996, Cambridge, England
  • Minisymposium speaker - "Mechanism of corneal endothelial cell inhibition of IL-2 production"
  • Annual FASEB Meeting, American Association of Immunologists, April, 1995, Atlanta, GA
  • “Unresponsiveness of self-peptides of S-antigen in EAU" Symposium on "Recent Developments in the Immunopathology of Intraocular Inflammation", 2nd International Meeting, October 22-25, 1991, Aberdeen, Scotland
  • "T cell receptors of S-Ag-specific uveitogenic T cells use Vb8 and Va2 genes; non-pathogenic T cells do not", 9th International Congress of Eye Research, (ICER), July 29-August 9, 1990, Helsinki, Finland